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CURRICULUM VITAE


Wenchao Yang, Ph.D. Associate Professor
Room 631, College of Chemistry
Central China Normal University
152 Luoyu Road, Wuhan Hubei Province
P. R. China 430079


CONTACT INFORMATION

Office:Chemistry Building, Room 631
Tel: +86-27-67867706
Mobile:+86-18171425138
E-mail: tomyang@mail.ccnu.edu.cn

EDUCATION

Post Doc. Pharmaceutical science, University of Kentucky (2010)

Ph.D.  Chemical Biology, Central China Normal University (June 2009)

Exchanged Ph.D. Pharmaceutical science, University of Kentucky (2005-2009)
B.S.     Chemical Education, Central China Normal University (June 2003).

POSITIONS

2012-present    Associate Professor, College of Chemistry, Central China Normal University

2009  Assistant ProfessorCollege of Chemistry, Central China Normal University


HONORS AND AWARDS

2012  Excellent Poster Award of the 4th Pesticide and Environmental Security International Academic Forum,5th Pan-Pacific Pesticide Scientific Conference& 8th Plant Chemical Protection and Global Regulation Integration International Forum

2012  2ed award for undergraduate teaching at college of chemistry of CCNU


RESEARCH BACKGROUND

Chemical biology & Biological chemistry

RESEARCH PUBLICATIONS

A.Peer-Reviewed Publications

  1. Li, J.; Zhang, C. F.; Ming, Z. Z.; Hao, G. F.; Yang, W. C. *; Yang, G. F.* Coumarin-based novel fluorescent zinc ion probe in aqueous solution. Tetrahedron 2013, In press.
  2. Peng, D. Y.; Sun, Q.; Zhu, X.L.; Lin, H.Y.; Chen, Q.; Yang, W. C. *; Yang, G. F. * Design, Synthesis, and Bioevaluation of Benzamides: Novel Acetylcholinesterase Inhibitors with Multi-functions on  Butylcholinesterase, Aβ Aggregation, and β-Secretase. Bioorg. Med. Chem. 2012, 20, 6739-6750.
  3. Yang, W. C.; Li, H.; Wang, F.; Zhu, X.L.; Yang, G. F. * Rieske Iron–Sulfur Protein of the Cytochrome bc1 Complex: A Potential Target for Fungicide Discovery. Chembiochem, 2012, 134, 1542-1551.
  4. Yang, W. C.; AbdulHameed M. D.; Hamza A.; Zhan C.G. * New inhibitor of 3-phosphoinositide dependent protein kinase-1 identified from virtual screening. Bioorg. Med. Chem. Lett. 2012, 15, 1629-1632.
  5. Yang, W. C.; Li J.; Li J.; Chen Q.; Yang G. F. * Novel synthetic methods for N-cyano-1H-imidazole-4-carboxamides and their fungicidal activity. Bioorg. Med. Chem. Lett., 2012, 22, 1455-1458.
  6. 杨文超, 孙琦, 喻熙, 朱晓磊, 杨光富*. 治疗阿尔茨海默病的乙酰胆碱酯酶抑制剂的分子设计:从多位点抑制剂到一药多靶. 药学学报 2012, 47, 313-321。
  7. Yang, W. C.; Pan, Y. M.; Fang, L.; Gao, D.; Zheng, F.; Zhan, C. G. Free energy perturbation simulation on transition states and high-activity mutants of human butyrylcholinesterase for (-)-cocaine hydrolysis. J. Phys. ChemB., 2010, 114, 10889-10896.
  8. Yang, W. C.; Xue, L.; Fang, L.; Chen, X.; Zhan, C. G. Characterization of a high-activity mutant butyrylcholinesterase against (-)-cocaine. Chem. Biol. Interact. 2010, 187, 148-152,
  9. Yang, W. C.; Pan, Y. M.; Zheng, F.; Cho, H.; Tai, H. H.; Zhan, C. G. Free-energy perturbation simulation on transition states and redesign of butyrylcholinesterase. Biophys J., 2009, 96, 1931-1938.
  10. Xue, L.; Hou, S.; Yang, W. C.; Fang, L.; Zheng, F.; Zhan, C. G. * Catalytic activities of a cocaine hydrolase engineered from human butyrylcholinesterase against (+)- and (-)-cocaine. Chem. Biol. Interact. 2013, 203, 57-62.
  11. Hao,G. F.; Wang, F.; Li, H.; Zhu, X. L.; Yang, W. C.; Huang, L. S.; Wu, J. W.; Edward, A. B.; Yang, G. F. * Computational Discovery of Picomolar Qo Site Inhibitors of Cytochrome bc1 Complex. J. Am. Chem. Soc., 2012,134, 11168-11176.
  12. Liu, J.; Zhao, X. Y.; Yang, W. C.; Zhan, C. G. * Reaction mechanism for cocaine esterase-catalyzed hydrolyses of (+)- and (-)-cocaine: unexpected common rate-determining step. J. Phys. Chem. B. 2011,115, 5017-5025.
  13. Xue, L.; Ko, M. C.; Tong, M.; Yang, W. C.; Hou, S.; Fang, L.; Liu, J.; Zheng, F.; Woods, J. H.; Tai, H. H.; Zhan, C. G. * Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine. Mol. Pharmacol. 2011, 79, 290-297. 
  14. Wang F.; Li H.; Wang L.; Yang, W. C.; Wu J. W.; Yang G. F. * Design, syntheses, and kinetic evaluation of 3-(phenylamino)oxazolidine-2,4-diones as potent cytochrome bc1 complex inhibitors. Bioorg. Med. Chem., 2011,19, 4608-4615.
  15. Zhu, X. L.; Yang, W. C.; Yu, N.; Yang, S.; Yang, G. F. * Computational simulations of structural role of the active-site W374C mutation of acetyl-coenzyme-A carboxylase: Multi-drug resistance mechanism. J. Mol. Model. 2011, 17, 495-503.
  16. Zheng, F.; Yang, W. C.; Xue, L.; Hou, S.; Zhan, C. G. * Design of high-activity mutants of human butyrylcholinesterase against (-)-cocaine: structural and energetic factors affecting the catalytic efficiency.Biochemistry, 2010, 49, 9113-9119.
  17. Zheng, F.; Yang, W. C.; Ko, M. C.; Liu, J. J.; Cho, H.; Gao, D.; Tong, M.; Tai, H. H.; Woods, J. H.; Zhan, C. G. * Most efficient cocaine hydrolase designed by virtual screening of transition states. J. Am. Chem. Soc. 2008, 130, 12148-12155.
  18. Pan, Y.; Gao, D.; Yang, W. C.; Cho, H.; Zhan, C. G. * Free energy perturbation (FEP) simulation on the transition states of cocaine hydrolysis catalyzed by human butyrylcholinesterase and its mutants. J. Am. Chem. Soc.2007129, 13537-13543.
  19. Zhu, X. L.; Wang, H.B.; Chen, Q.; Yang, W. C.; Yang, G.F. *. Preparation and characterization of inclusion complex of iprodione and beta-cyclodextrin to improve fungicidal activity. J. Agric. Food Chem. 200755, 3535-3539.
  20. Yang, G.F.;* Wang, H.B.; Yang, W. C.; Gao, D.; Zhan, C. G. * Formation of supramolecular permethrin/beta-cyclodextrin nanorods. J. Chem. Phys. 2006, 125, 111104. Erratum in: J. Chem. Phys. 2007,126, 059902.
  21. Yang, G.F.;* Wang, H.B.; Yang, W. C.; Gao, D.; Zhan, C. G. * Bioactive permethrin/beta-cyclodextrin inclusion complex. J. Phys. Chem. B. 2006, 110, 7044-7048.
  22. Gao, D.; Cho, H.’ Yang, W. C.; Pan, Y.; Yang, G.F.; Tai, H.H.; Zhan, C. G. * Computational design of a human butyrylcholinesterase mutant for accelerating cocaine hydrolysis based on the transition-state simulation. Angew.Chem. Int. Ed. Engl.2006, 45, 653-657.
  23. Pan, Y.; Gao, D.; Yang, W. C.; Cho, H.;Tai, H.H.; Zhan, C. G. * Computational redesign of human butyrylcholinesterase for anticocaine medication. Proc. Natl. Acad. Sci. U S A. 2005102, 16656-16661.

B. Patents

  1. “High activity mutants of butyrylcholinesterase for cocaine hydrolysis” Zhan, C. G.; Zheng, F.; Yang, W. C.Patent #US7740840B1.US patent
  2. “High activity mutants of butyrylcholinesterase for cocaine hydrolysis” Zhan, C. G.; Zheng, F.; Yang, W. C.Patent #US7892537B1.US patent
  3. “High activity mutants of butyrylcholinesterase for cocaine hydrolysis” Zhan, C. G.; Zheng, F.; Yang, W. C.Patent #US 8206703.US patent
  4. 香豆素衍生物及其制备方法以及弹性蛋白酶检测方法和检测试剂盒。杨光富,杨文超,李俊,孙琦,张春芳。申请号:201310086356.7,发明专利, 中国。chinese patent
  5. 蛋白水解酶活性的荧光检测方法。杨光富,杨文超,孙琦,李俊,刘万年。申请准备中,发明专利, 中国。chinese patent

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Key Laboratory of Pesticide & Chemical Biology of Ministry of Education
College of Chemistry · Central China Normal University

Last update: Aug 20, 2016 · By: Chengzhang Li