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CURRICULUM VITAE


 Xiao-Lei Zhu, Ph.D.Associate Professor
Room 631, College of Chemistry
Central China Normal University
152 Luoyu Road, Wuhan Hubei Province
P. R. China 430079


CONTACT INFORMATION

Office:Chemistry Building, Room 631
Tel:+86-27-67867706
Mobile: +86-15327348018
E-mail:xlzhu@mail.ccnu.edu.cn

EDUCATION

Ph.D.   Pesticide Chemistry,Central China Normal University (December 2008)
B.S.     Chemistry, AnQing Normal University.(June 2003).

HONORS AND AWARDS

2012 Excellent Poster Award of the 4th “Pesticide and Environmental Security” InternationalAcademic Forum, 5th “Pan-Pacific Pesticide Scientific Conference”& 8th “Plant Chemical Protection and Global Regulation Integration” International Forum
2008 Excellent Poster Award of the International Conference on Theoretical & High Performance Computational Chemistry

RESEARCH BACKGROUND

Computational biology

RESEARCH PUBLICATIONS

A.Peer-Reviewed Publications

  1. Zhu,X. L.; Yu, N. X.; Hao,G.F.; Yang, W. C.; Yang, G. F*. Structural basis of femtomolar inhibitorsfor acetylcholinesterase subtype selectivity: Insights from computationalsimulations. J. Mol Grap Model. 2013, 41, 55-60.
  2. Zhu,X. L.;Yang, G. F*. A Comparative Studyof Drug Resistance Mechanism Associated with Active Site and Non-Active SiteMutations: I388N and D425GMutants of Acetyl-Coenzyme-A. Carboxylase.Curr Comput-Aided Drug Des, 2012,8, 62-69.
  3. Zhu, X. L.; Wang, F.; Li, H.; Yang, W. C.; Chen, Q.; Yang, G. F*.Design, Synthesis, and Bioevaluation ofNovel Strobilurin Derivatives.Chin. J. Chem. 2012, 30,1999-2008
  4. Zhu,X. L.; Yang, W. C.; Yu, N.X.; Yang, S. G.; Yang, G. F*. Computational Simulations of StructuralRole of the Active-site W374CMutation of Acetyl-Coenzyme-A Carboxylase: Multi-drug Resistance Mechanism.J. Mol. Model. 2011, 17,495-503.
  5. Zhu,X. L.; Hao, G. F.; Zhan,C. G.;* Yang, G. F*.Computational Simulations of the Interactions between Acetyl-Coenzyme-ACarboxylase and Clodinafop: Resistance Mechanism Due to Active and NonactiveSite Mutations. J. Chem. Inf. Model. 2009, 49, 1936-1943.
  6. Zhu, X. L.; Wang, H. B.; Chen, Q.; Yang, W. C.; Yang, G. F*. Preparation and Characterization of Inclusion Complex of Iprodione andα-Cyclodextrin to Improve Fungicidal Activity.J. Agric. Food Chem. 2007,55, 3535-3539.
  7. Zhu, X. L.; Zhang, L.; Chen, Q.; Wan, J.; Yang, G. F*.Interactionsof Aryloxyphenoxy- propionic Acids with Sensitive and Resistant Acetyl-CoenzymeA Carboxylase by Homology Modeling and Molecular Dynamic Simulations. J.Chem. Inf. Model. 2006, 46, 1819-1826.
  8. Zhan,Junyan; Zhu, Xiao lei; Fang, Fei; Miao, Fajun; Tian, Demei;Li, Haibing*.  Sensitive fluorescence sensor for nitroaniline isomersbased on calix[4]arene bearing naphthyl groups. Tetrahedron, 2012, 68, 5579-5582.
  9. Zhang, G. F.; Zhu, X. L.;Miao, F. J.; Tian, D. M.; Li, H. B*. Design ofswitchable wettability sensor for paraquat based on clicking calix[4]arene. Org Biomol Chem, 2012, 10, 3185-3188. 
  10. Huang, Tong-Hui; Zhu, Xiao-Lei; Zhang,Ai-Dong*; Tu, Hai-Yang. Facile Synthesis of Alternating Benzene-PyrroleOligomers by Cyclization of Propargylic Dithioacetals and Imines and TheirFluorescent Properties.Eur. J. Med. Chem2011, 24,4588-4594.
  11. Hao,G. F., Zhu, X. L.; Ji, F. Q.; Zhang, L.; Yang, G. F.; Zhan, C. G.Understanding Mechanism of Drug Resistance Due to a Codon Deletion inProtoporphrinogen Oxidase through Computational Modeling. J. Phys. Chem. B,2009, 113, 4865-4875
  12. Chen,Q.; Zhu, X. L.; Jiang, L. L.; Liu, Z. M.; Yang, G. F. Synthesis,Antifungal Activity and CoMFA Analysis of Novel 1,2,4-Triazolo[1,5-a]PyrimidineDerivatives. Eur. J. Med. Chem. 2008, 43,595-603.
  13. Hao,G. F., Wang, F.; Li, H.; Zhu, X. L.; Yang, W. C.;Huang, L.S.; Wu, J.W.;Berry. E. A.; Yang, G. F*. Computational Discovery of Picomolar Qo SiteInhibitors of Cytochrome bc1 Complex.J. Am. Chem. Soc.2012,134, 11168-11176.
  14. Zhao,P. L.; Wang, L.; Zhu, X. L.; Huang, X.; Zhan, C. G.; Wu, J. W.; Yang, G.F. Subnanomolar Inhibitor of Cytochrome bc1 Complex Designed by OptimizingInteraction with Conformationally Flexible Residues. J. Am. Chem. Soc. 2010,132, 185-194.
  15. Jiang,L. L.; Tan, Y.; Zhu, X. L.; Wang, Z. F.; Zuo, Y.; Chen, Q.; Xi, Z.;Yang, G. F. Design, Synthesis and 3D-QSAR Analysis of Novel1,3,4-Oxadiazol-2(3H)-ones as Protoporphyrinogen oxidase Inhibitors. J.Agric. Food Chem2010, 58, 2643-2651.
  16. Tan,Shi-Miao; Jiao, Jian; Zhu, Xiao-Lei; *Zhou, Yan-Ping; Song,Dan-Dan; Gong, Hong; Yu, Ru-Qin QSAR studies of adiverse series of antimicrobial agents against Candida albicans byclassification and regression trees.Chemometricsand Intelligent Laboratory Systems, 2010, 103, 184-190.
  17. He, Y.Z.; Li, Y. X.; Zhu, X. L.; Xi, Z.; Niu, C. W.; Zhang, L.; Yang, G. F.*Rational Design and Interaction Mechanism of Pyrimidinylbenzoates with Acetohydroxyacid Synthase Based on Bioactive Conformation Analysis by Integrating Molecular Docking, CoMFA, CoMSIA and DFT Calculations. J. Chem.Inf. Model2007, 47, 2335-2344.

B. Book Chapters

XiaoLei Zhu etc. Chapter 14 New Heterocyclic Pesticide: Insecticide. edited by Bao-An Song, Chemical Industry Press, Beijing, 2010

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Key Laboratory of Pesticide & Chemical Biology of Ministry of Education
College of Chemistry · Central China Normal University

Last update: Aug 20, 2016 · By: Chengzhang Li