Synthetic Methodologies of Novel Heterocyclic Compounds
Organic compounds whose molecules contain one or more rings of atoms with at least one atom being an element other than carbon, most frequently oxygen, nitrogen, or sulfur, are called heterocyclic compounds. Almost half of the all known compounds contain heterocyclic rings, and many of these are aromatic heterocyclic rings. Heteroaromatics are found in many of the products such as drugs and pesticides. Due to their vital importance, synthetic methodologies of heteroaromatic compounds still represent a very active area of current research.
The development of new methodologies for synthesis of heteroaromatic compounds has remained a highly attractive but challenging proposition. Microwave heating has emerged as a powerful technique to promote a variety of chemical reactions. Under solvent-free conditions, it is attractive in offering reduced pollution and offering low cost together with simplicity in processing and handling. In the last few years, the application of microwave irradiation has greatly facilitated the construction of such heterocyclic ring systems through a myriad of different synthetic approaches. The microwave-assisted synthesis has been applied almost on all types of chemical reactions such as additions, cycloadditions, substitutions, eliminations,fragmentations etc. in our group. For example, we constructed of a combinatorial library of 2-(4-Oxo-4H-1-Benzopyran-3-yl)-4-Thiazolidinones by microwave-assisted one-pot parallel syntheses and we studied an efficient intramolecular stetter reaction by microwave irradiation. Undoubtedly, microwaves are going to be highly important in future synthesis of heterocycles.