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Tar-R-M server: A Target Identification Tools based on Reverse-docking and MD
 

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Tar-R-M Server: a web sever


       Drug target identification, which includes many distinct algorithms for finding genes and proteins, is the first step in drug discovery. When 3D structures of the targets are available, the problem of target identification is usually converted to finding the best interaction mode between the potential target candidates and probe small molecules.

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       Tar-R-M Server is a freely accessed web-server designed to identify potential target candidates for the given probe small molecules (drugs, natural products, or other newly discovered compounds with binding targets unidentified) using reverse-docking and MD approach.

       Tar-R-M sever is backed up by a large, in-house pesticide-related targets 3D structure database extracted from all the targets in TargetBank, DrugBank, BindingDB, PDB, PDTD. And a in-house cancer-related targets database.

       To use Tar-R-M server, please upload your molecule file in Submit Job page. The job information as well as the structures of submitted molecules is invisible between different users. Here is a sample output of identified targets for PPO.


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