IUPAC name
2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide
SMILES
COC1=CC(C(O)CNC(=O)CN)=C(OC)C=C1
Compound class
Vasoconstrictor Agents; Sympathomimetics; Adrenergic alpha-1 Receptor Agonists; Cardiovascular System; Cardiac Therapy; Adrenergic and Dopaminergic Agents; Cardiac Stimulants Excl. Cardiac Glycosides; CYP2D6 Inducers; CYP2D6 Inducers (strong);
Therapeutic area
For the treatment of symptomatic orthostatic hypotension (OH).
Common name
Midodrine
IUPAC name
2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide
SMILES
COC1=CC(C(O)CNC(=O)CN)=C(OC)C=C1
INCHI
InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16)
FORMULA
C12H18N2O4
Common name
Midodrine
IUPAC name
2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide
Molecular weight
254.282
clogP
0.603
clogS
-2.128
HBond Acceptor
4
HBond Donor
4
Total Polar Surface Area
93.81
Number of Rings
1
Rotatable Bond
6
| Drug ID | Common name | Structure CAS | SMILE | Frequency |
|---|---|---|---|---|
| FDBF00043 | N-(2-hydroxyethyl)formamide |
|
C(CO)NC=O | 0.0065 |
| FDBF00211 | anisole |
|
COc1ccccc1 | 0.0423 |
| FDBF00304 | phenylmethanol |
|
c1(ccccc1)CO | 0.0168 |
| FDBF00311 | (3-methoxyphenyl)methanol |
|
C(O)c1cccc(c1)OC | 0.0007 |
| FDBF00313 | N-[(2S)-2-hydroxy-2-phenyl-ethyl]formamide |
|
C(C(O)c1ccccc1)NC=O | 0.0003 |
| FDBF00316 | (1R)-1-(2,5-dimethoxyphenyl)ethanol |
|
CC(O)c1c(ccc(c1)OC)OC | 0.0003 |
16 ,
2
