IUPAC name
3-ethyl-4-methyl-N-{2-[4-({[(4-methylcyclohexyl)carbamoyl]amino}sulfonyl)phenyl]ethyl}-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
SMILES
CCC1=C(C)CN(C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC2CCC(C)CC2)C1=O
Compound class
Hypoglycemic Agents; Immunosuppressive Agents; Anti-Arrhythmia Agents; Drugs Used in Diabetes; Alimentary Tract and Metabolism; Blood Glucose Lowering Drugs, Excl. Insulins; Sulfonylureas; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP2C9 Inducers;
Therapeutic area
For concomitant use with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus.
Common name
Glimepiride
IUPAC name
3-ethyl-4-methyl-N-{2-[4-({[(4-methylcyclohexyl)carbamoyl]amino}sulfonyl)phenyl]ethyl}-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
SMILES
CCC1=C(C)CN(C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC2CCC(C)CC2)C1=O
INCHI
InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)
FORMULA
C24H34N4O5S
Common name
Glimepiride
IUPAC name
3-ethyl-4-methyl-N-{2-[4-({[(4-methylcyclohexyl)carbamoyl]amino}sulfonyl)phenyl]ethyl}-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
Molecular weight
490.616
clogP
1.856
clogS
-5.488
HBond Acceptor
5
HBond Donor
3
Total Polar
Surface Area
124.68
Number of Rings
3
Rotatable Bond
8
| Drug ID | Common name | Structure CAS | SMILE | Frequency |
|---|---|---|---|---|
| FDBF00005 | benzene |
|
c1ccccc1 | 0.2824 |
| FDBF00023 | toluene |
|
c1(ccccc1)C | 0.1268 |
| FDBF00141 | ethylbenzene |
|
c1(ccccc1)CC | 0.0371 |
| FDBF00319 | methylcyclohexane |
|
CC1CCCCC1 | 0.0038 |
| FDBF00418 | N,3-dimethyl-5-oxo-2H-pyrrole-1-carboxamide |
|
CNC(=O)N1C(=O)C=C(C1)C | 0.0003 |
| FDBF00419 | N-ethyl-3-methyl-5-oxo-2H-pyrrole-1-carboxamide |
|
CCNC(=O)N1C(=O)C=C(C1)C | 0.0003 |
| FDBF00420 | 4-ethyl-N,3-dimethyl-5-oxo-2H-pyrrole-1-carboxamide |
|
C(C)C1=C(CN(C1=O)C(=O)NC)C | 0.0003 |
| FDBF00421 | N,4-diethyl-3-methyl-5-oxo-2H-pyrrole-1-carboxamide |
|
C(C)C1=C(CN(C1=O)C(=O)NCC)C | 0.0003 |
