IUPAC name
6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-2H-1λ
SMILES
CN1C(CCl)NC2=CC(Cl)=C(C=C2S1(=O)=O)S(N)(=O)=O
Compound class
Diuretics; Sodium Chloride Symporter Inhibitors; Cardiovascular System; Thiazides, Plain; Low-Ceiling Diuretics, Thiazides;
Therapeutic area
For use in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension. Also used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.
Common name
Methyclothiazide
IUPAC name
6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-2H-1λ
SMILES
CN1C(CCl)NC2=CC(Cl)=C(C=C2S1(=O)=O)S(N)(=O)=O
INCHI
InChI=1S/C9H11Cl2N3O4S2/c1-14-9(4-10)13-6-2-5(11)7(19(12,15)16)3-8(6)20(14,17)18/h2-3,9,13H,4H2,1H3,(H2,12,15,16)
FORMULA
C9H11Cl2N3O4S2
Common name
Methyclothiazide
IUPAC name
6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-2H-1λ
Molecular weight
360.237
clogP
-0.538
clogS
-2.994
HBond Acceptor
4
HBond Donor
3
Total Polar Surface Area
109.57
Number of Rings
2
Rotatable Bond
2
| Drug ID | Common name | Structure CAS | SMILE | Frequency |
|---|---|---|---|---|
| FDBF00472 | (3R)-6-chloro-3-(chloromethyl)-2-methyl-3,4-dihydrobenzo[e][1,2,4]thiadiazine 1,1-dioxide |
|
Clc1cc2c(cc1)S(=O)(=O)N(C(N2)CCl)C | 0.0003 |
| FDBF00473 | 6-chloro-2-methyl-3,4-dihydrobenzo[e][1,2,4]thiadiazine 1,1-dioxide |
|
Clc1cc2c(cc1)S(=O)(=O)N(CN2)C | 0.0007 |
