Responsive image

Common name


Clotrimazole

IUPAC name


1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole

SMILES


ClC1=CC=CC=C1C(N1C=CN=C1)(C1=CC=CC=C1)C1=CC=CC=C1

Compound class


Antifungal Agents; 14-alpha Demethylase Inhibitors; Anti-Infective Agents, Local; Genito Urinary System and Sex Hormones; Alimentary Tract and Metabolism; Antiinfectives for Systemic Use; Stomatological Preparations; Dermatologicals; Gynecological Antiinfectives and Antiseptics; Imidazole and Triazole Derivatives; Antifungals for Topical Use; Antifungals for Dermatological Use; Antimycotics for Systemic Use; Imidazole Derivatives; Antiinfectives and Antiseptics for Local Oral Treatment; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP1A2 Inducers; Cytochrome P-450 CYP2C8 Inhibitors; Cytochrome P-450 CYP2C9 Inducers; Cytochrome P-450 CYP2C19 Inducers; Cytochrome P-450 CYP2C8 Inducers; Cytochrome P-450 CYP2B6 Inducers; Cytochrome P-450 CYP2B6 Inhibitors; CYP2A6 Inhibitors; CYP2A6 Inhibitors (strong); CYP2A6 Inhibitors (moderate); CYP2A6 Inducers; CYP2A6 Inducers (strong); CYP2B6 Inhibitors (strong); CYP2D6 Inducers; CYP2D6 Inducers (strong); CYP2E1 Inhibitors; CYP2E1 Inducers; CYP2E1 Inducers (strong); CYP3A4 Inhibitors; Combined Inducers of CYP3A4 and P-glycoprotein; Combined Inhibitors of CYP3A4 and P-glycoprotein;

Therapeutic area


For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch.

Common name


Clotrimazole

IUPAC name


1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole

SMILES


ClC1=CC=CC=C1C(N1C=CN=C1)(C1=CC=CC=C1)C1=CC=CC=C1

INCHI


InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H

FORMULA


C22H17ClN2

Responsive image

Common name


Clotrimazole

IUPAC name


1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole

Molecular weight


344.837

clogP


4.977

clogS


-6.016

HBond Acceptor


1

HBond Donor


0

Total Polar
Surface Area


17.82

Number of Rings


4

Rotatable Bond


4

Drug ID Common name Structure CAS SMILE Frequency
FDBF00005 benzene Responsive image c1ccccc1 0.2824
FDBF00011 imidazole Responsive image [nH]1ccnc1 0.0175
FDBF00016 chlorobenzene Responsive image c1ccc(cc1)Cl 0.0718
FDBF00023 toluene Responsive image c1(ccccc1)C 0.1268
FDBF00302 1-chloro-2-methyl-benzene Responsive image Clc1c(cccc1)C 0.0062
FDBF00490 1-methylimidazole Responsive image n1(ccnc1)C 0.0058
FDBF00541 1-[(2-chlorophenyl)methyl]imidazole Responsive image Clc1c(cccc1)Cn2ccnc2 0.0003
FDBF00542 1-benzylimidazole Responsive image n1(ccnc1)Cc2ccccc2 0.0007
FDBF00543 1-[(S)-(2-chlorophenyl)-phenyl-methyl]imidazole Responsive image Clc1c(cccc1)C(n2ccnc2)c3ccccc3 0.0003
FDBF00545 1-benzhydrylimidazole Responsive image n1(ccnc1)C(c2ccccc2)c3ccccc3 0.0007
11 , 2