
IUPAC name
1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole
SMILES
ClC1=CC=CC=C1C(N1C=CN=C1)(C1=CC=CC=C1)C1=CC=CC=C1
Compound class
Antifungal Agents; 14-alpha Demethylase Inhibitors; Anti-Infective Agents, Local; Genito Urinary System and Sex Hormones; Alimentary Tract and Metabolism; Antiinfectives for Systemic Use; Stomatological Preparations; Dermatologicals; Gynecological Antiinfectives and Antiseptics; Imidazole and Triazole Derivatives; Antifungals for Topical Use; Antifungals for Dermatological Use; Antimycotics for Systemic Use; Imidazole Derivatives; Antiinfectives and Antiseptics for Local Oral Treatment; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP1A2 Inducers; Cytochrome P-450 CYP2C8 Inhibitors; Cytochrome P-450 CYP2C9 Inducers; Cytochrome P-450 CYP2C19 Inducers; Cytochrome P-450 CYP2C8 Inducers; Cytochrome P-450 CYP2B6 Inducers; Cytochrome P-450 CYP2B6 Inhibitors; CYP2A6 Inhibitors; CYP2A6 Inhibitors (strong); CYP2A6 Inhibitors (moderate); CYP2A6 Inducers; CYP2A6 Inducers (strong); CYP2B6 Inhibitors (strong); CYP2D6 Inducers; CYP2D6 Inducers (strong); CYP2E1 Inhibitors; CYP2E1 Inducers; CYP2E1 Inducers (strong); CYP3A4 Inhibitors; Combined Inducers of CYP3A4 and P-glycoprotein; Combined Inhibitors of CYP3A4 and P-glycoprotein;
Therapeutic area
For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch.
Common name
Clotrimazole
IUPAC name
1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole
SMILES
ClC1=CC=CC=C1C(N1C=CN=C1)(C1=CC=CC=C1)C1=CC=CC=C1
INCHI
InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
FORMULA
C22H17ClN2

Common name
Clotrimazole
IUPAC name
1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole
Molecular weight
344.837
clogP
4.977
clogS
-6.016
HBond Acceptor
1
HBond Donor
0
Total Polar Surface Area
17.82
Number of Rings
4
Rotatable Bond
4
Drug ID | Common name | Structure CAS | SMILE | Frequency |
---|---|---|---|---|
FDBF00005 | benzene |
![]() |
c1ccccc1 | 0.2824 |
FDBF00011 | imidazole |
![]() |
[nH]1ccnc1 | 0.0175 |
FDBF00016 | chlorobenzene |
![]() |
c1ccc(cc1)Cl | 0.0718 |
FDBF00023 | toluene |
![]() |
c1(ccccc1)C | 0.1268 |
FDBF00302 | 1-chloro-2-methyl-benzene |
![]() |
Clc1c(cccc1)C | 0.0062 |
FDBF00490 | 1-methylimidazole |
![]() |
n1(ccnc1)C | 0.0058 |
FDBF00541 | 1-[(2-chlorophenyl)methyl]imidazole |
![]() |
Clc1c(cccc1)Cn2ccnc2 | 0.0003 |
FDBF00542 | 1-benzylimidazole |
![]() |
n1(ccnc1)Cc2ccccc2 | 0.0007 |
FDBF00543 | 1-[(S)-(2-chlorophenyl)-phenyl-methyl]imidazole |
![]() |
Clc1c(cccc1)C(n2ccnc2)c3ccccc3 | 0.0003 |
FDBF00545 | 1-benzhydrylimidazole |
![]() |
n1(ccnc1)C(c2ccccc2)c3ccccc3 | 0.0007 |