IUPAC name
(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.0²,
SMILES
[H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C
Compound class
Anti-Allergic Agents; Anti-Inflammatory Agents; Glucocorticoids; Anti-Acne Preparations; Corticosteroids; Ophthalmologicals; Sensory Organs; Dermatologicals; Anti-Acne Preparations for Topical Use; Cardiovascular System; Corticosteroids, Plain; Corticosteroids, Dermatological Preparations; Corticosteroids, Moderately Potent (Group II); Antiinflammatory Agents; Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use; Vasoprotectives; CYP3A4 Inhibitors;
Therapeutic area
For the ophthalmic treatment of corticosteroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe.
Common name
Fluorometholone
IUPAC name
(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.0²,
SMILES
[H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C
INCHI
InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1
FORMULA
C22H29FO4
Common name
Fluorometholone
IUPAC name
(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.0²,
Molecular weight
376.462
clogP
3.186
clogS
-3.368
HBond Acceptor
4
HBond Donor
2
Total Polar Surface Area
74.6
Number of Rings
4
Rotatable Bond
1
