IUPAC name
4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
SMILES
C[C@@H](CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1
Compound class
Antineoplastic Agents; Cardiotonic Agents; Chelating Agents; Cardiovascular Agents; Topoisomerase II Inhibitors; Detoxifying Agents for Antineoplastic Treatment;
Therapeutic area
For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin hydrochloride dose of 300 mg/m^2 and would benefit from continued doxorubicin therapy. Also approved for the treatment of extravasation from intravenous anthracyclines.
Common name
Dexrazoxane
IUPAC name
4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
SMILES
C[C@@H](CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1
INCHI
InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1
FORMULA
C11H16N4O4
Common name
Dexrazoxane
IUPAC name
4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
Molecular weight
268.269
clogP
-0.680
clogS
-1.272
HBond Acceptor
6
HBond Donor
2
Total Polar Surface Area
98.82
Number of Rings
2
Rotatable Bond
3
| Drug ID | Common name | Structure CAS | SMILE | Frequency |
|---|---|---|---|---|
| FDBF00007 | propane |
|
C(C)C | 0.2412 |
| FDBF00834 | 4-ethylpiperazine-2,6-dione |
|
C(C)N1CC(=O)NC(=O)C1 | 0.0003 |
| FDBF00835 | 4-methylpiperazine-2,6-dione |
|
CN1CC(=O)NC(=O)C1 | 0.0003 |
| FDBF00836 | 4-isopropylpiperazine-2,6-dione |
|
CC(C)N1CC(=O)NC(=O)C1 | 0.0003 |
| FDBF00837 | 4-propylpiperazine-2,6-dione |
|
C(CC)N1CC(=O)NC(=O)C1 | 0.0003 |
