IUPAC name
N-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide
SMILES
CN(C(=S)OC1=CC2=CC=CC=C2C=C1)C1=CC=CC(C)=C1
Compound class
Antifungal Agents; Dermatologicals; Antifungals for Topical Use; Antifungals for Dermatological Use;
Therapeutic area
Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot.
Common name
Tolnaftate
IUPAC name
N-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide
SMILES
CN(C(=S)OC1=CC2=CC=CC=C2C=C1)C1=CC=CC(C)=C1
INCHI
InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3
FORMULA
C19H17NOS
Common name
Tolnaftate
IUPAC name
N-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide
Molecular weight
307.409
clogP
5.071
clogS
-4.914
HBond Acceptor
2
HBond Donor
0
Total Polar Surface Area
44.56
Number of Rings
3
Rotatable Bond
4
| Drug ID | Common name | Structure CAS | SMILE | Frequency |
|---|---|---|---|---|
| FDBF00023 | toluene |
|
c1(ccccc1)C | 0.1268 |
| FDBF01181 | 1,4-dihydronaphthalen-2-ol |
|
OC1=CCc2c(cccc2)C1 | 0.0003 |
| FDBF01182 | (N,3-dimethylanilino)methanethiol |
|
SCN(C)c1cc(ccc1)C | 0.0003 |
| FDBF01183 | methyl(m-tolyl)carbamothioic S-acid |
|
SC(=O)N(C)c1cc(ccc1)C | 0.0003 |
| FDBF01184 | methylaminomethanethiol |
|
SCNC | 0.0003 |
