Responsive image

Common name


Sulindac

IUPAC name


2-[(1Z)-5-fluoro-1-[(4-methanesulfinylphenyl)methylidene]-2-methyl-1H-inden-3-yl]acetic acid

SMILES


CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(C=C1)S(C)=O

Compound class


Antineoplastic Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Musculo-Skeletal System; Acetic Acid Derivatives and Related Substances; Antiinflammatory and Antirheumatic Products, Non-Steroids; Antiinflammatory and Antirheumatic Products; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP1A2 Inducers;

Therapeutic area


For acute or long-term use in the relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute painful shoulder (acute subacromial bursitis/supraspinatus tendinitis), and acute gouty arthritis.

Common name


Sulindac

IUPAC name


2-[(1Z)-5-fluoro-1-[(4-methanesulfinylphenyl)methylidene]-2-methyl-1H-inden-3-yl]acetic acid

SMILES


CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(C=C1)S(C)=O

INCHI


InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-

FORMULA


C20H17FO3S

Responsive image

Common name


Sulindac

IUPAC name


2-[(1Z)-5-fluoro-1-[(4-methanesulfinylphenyl)methylidene]-2-methyl-1H-inden-3-yl]acetic acid

Molecular weight


356.411

clogP


4.259

clogS


-5.491

HBond Acceptor


3

HBond Donor


1

Total Polar
Surface Area


54.37

Number of Rings


3

Rotatable Bond


4

Drug ID Common name Structure CAS SMILE Frequency
FDBF00004 acetic acid Responsive image CC(=O)O 0.0687
FDBF00005 benzene Responsive image c1ccccc1 0.2824
FDBF00356 hydroxysulfanylmethane Responsive image S(O)C 0.0069
FDBF01375 [hydroxy(methyl)-λ3-sulfanyl]benzene Responsive image c1ccc(cc1)[S](O)C 0.0010
FDBF01376 2-(6-fluoro-2,3-dimethyl-5H-inden-1-yl)acetic acid Responsive image C(C(=O)O)C1=C2C=C(CC=C2C(=C1C)C)F 0.0003
5 , 1