IUPAC name
1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1λ
SMILES
NS(=O)(=O)C1=CC2=C(NCNS2(=O)=O)C=C1C(F)(F)F
Compound class
Antihypertensive Agents; Diuretics; Sodium Chloride Symporter Inhibitors; Cardiovascular System; Thiazides, Plain; Low-Ceiling Diuretics, Thiazides;
Therapeutic area
Used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Also used in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
Common name
Hydroflumethiazide
IUPAC name
1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1λ
SMILES
NS(=O)(=O)C1=CC2=C(NCNS2(=O)=O)C=C1C(F)(F)F
INCHI
InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)
FORMULA
C8H8F3N3O4S2
Common name
Hydroflumethiazide
IUPAC name
1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1λ
Molecular weight
331.292
clogP
-0.557
clogS
-2.821
HBond Acceptor
4
HBond Donor
4
Total Polar Surface Area
118.36
Number of Rings
2
Rotatable Bond
2
| Drug ID | Common name | Structure CAS | SMILE | Frequency |
|---|---|---|---|---|
| FDBF00177 | fluoroform |
|
FC(F)F | 0.0704 |
| FDBF00953 | 6-(trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide |
|
FC(F)(F)c1ccc2c(c1)NCNS2(=O)=O | 0.0007 |
| FDBF00956 | 3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide |
|
S1(=O)(=O)NCNc2c1cccc2 | 0.0007 |
