IUPAC name
6-chloro-1,1-dioxo-4H-1λ
SMILES
NS(=O)(=O)C1=C(Cl)C=C2NC=NS(=O)(=O)C2=C1
Compound class
Antihypertensive Agents; Diuretics; Sodium Chloride Symporter Inhibitors; Cardiovascular System; Thiazides, Plain; Low-Ceiling Diuretics, Thiazides;
Therapeutic area
Chlorothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.
Common name
Chlorothiazide
IUPAC name
6-chloro-1,1-dioxo-4H-1λ
SMILES
NS(=O)(=O)C1=C(Cl)C=C2NC=NS(=O)(=O)C2=C1
INCHI
InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
FORMULA
C7H6ClN3O4S2
Common name
Chlorothiazide
IUPAC name
6-chloro-1,1-dioxo-4H-1λ
Molecular weight
295.723
clogP
-0.287
clogS
-2.332
HBond Acceptor
4
HBond Donor
3
Total Polar Surface Area
118.69
Number of Rings
2
Rotatable Bond
1
| Drug ID | Common name | Structure CAS | SMILE | Frequency |
|---|---|---|---|---|
| FDBF01278 | 6-chloro-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide |
|
Clc1ccc2c(c1)NC=NS2(=O)=O | 0.0007 |
