Responsive image

Common name


Desipramine

IUPAC name


(3-{2-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}propyl)(methyl)amine

SMILES


CNCCCN1C2=CC=CC=C2CCC2=CC=CC=C12

Compound class


Enzyme Inhibitors; Adrenergic Uptake Inhibitors; Antidepressive Agents, Tricyclic; Antidepressive Agents; Nervous System; Antidepressants; Psychoanaleptics; Non-Selective Monoamine Reuptake Inhibitors; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP1A2 Inducers; Cytochrome P-450 CYP2C19 Inducers; Cytochrome P-450 CYP2B6 Inducers; Cytochrome P-450 CYP2B6 Inhibitors; CYP2A6 Inhibitors; CYP2A6 Inhibitors (strong); CYP2A6 Inhibitors (moderate); CYP2A6 Inducers; CYP2A6 Inducers (strong); CYP2B6 Inhibitors (strong); CYP2D6 Inducers; CYP2D6 Inducers (strong); CYP2E1 Inhibitors; CYP2E1 Inducers; CYP2E1 Inducers (strong); CYP3A4 Inhibitors; Combined Inhibitors of CYP3A4 and P-glycoprotein;

Therapeutic area


For relief of symptoms in various depressive syndromes, especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain, as a second line agent for the management of anxiety disorders (e.g. panic disorder, generalized anxiety disorder), and as a second or third line agent in the ADHD management.

Common name


Desipramine

IUPAC name


(3-{2-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}propyl)(methyl)amine

SMILES


CNCCCN1C2=CC=CC=C2CCC2=CC=CC=C12

INCHI


InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3

FORMULA


C18H22N2

Responsive image

Common name


Desipramine

IUPAC name


(3-{2-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}propyl)(methyl)amine

Molecular weight


266.381

clogP


3.702

clogS


-5.245

HBond Acceptor


1

HBond Donor


1

Total Polar
Surface Area


15.27

Number of Rings


3

Rotatable Bond


4

Drug ID Common name Structure CAS SMILE Frequency
FDBF00007 propane Responsive image C(C)C 0.2412
FDBF00066 N-methylmethanamine Responsive image N(C)C 0.0914
FDBF00068 N-methylethanamine Responsive image N(CC)C 0.0429
FDBF00069 N-methylpropan-1-amine Responsive image N(CCC)C 0.0148
4 , 1