IUPAC name
tris(aziridin-1-yl)-λ
SMILES
S=P(N1CC1)(N1CC1)N1CC1
Compound class
Antineoplastic Agents; Immunosuppressive Agents; Antineoplastic Agents, Alkylating; Alkylating Agents; Myeloablative Agonists; Antineoplastic and Immunomodulating Agents; Ethylene Imines; Cytochrome P-450 CYP2B6 Inducers; Cytochrome P-450 CYP2B6 Inhibitors; CYP2B6 Inhibitors (strong); CYP3A4 Inhibitors;
Therapeutic area
ThioTEPA is used a as conditioning treatment prior to allogeneic or autologous haematopoietic progenitor cell transplantation (HPCT) in haematological diseases in adult and paediatric patients. Also, when high dose chemotherapy with HPCT support it is appropriate for the treatment of solid tumours in adult and paediatric patients.
Common name
Thiotepa
IUPAC name
tris(aziridin-1-yl)-λ
SMILES
S=P(N1CC1)(N1CC1)N1CC1
INCHI
InChI=1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2
FORMULA
C6H12N3PS
Common name
Thiotepa
IUPAC name
tris(aziridin-1-yl)-λ
Molecular weight
189.218
clogP
1.328
clogS
0.235
HBond Acceptor
1
HBond Donor
0
Total Polar Surface Area
50.93
Number of Rings
3
Rotatable Bond
3
