Responsive image

Common name


Droxidopa

IUPAC name


(2R,3S)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid

SMILES


N[C@H]([C@@H](O)C1=CC(O)=C(O)C=C1)C(O)=O

Compound class


Antiparkinson Agents; Cardiovascular System; Cardiac Therapy; Adrenergic and Dopaminergic Agents; Cardiac Stimulants Excl. Cardiac Glycosides; Beta2 Agonists; Alpha2 Agonists;

Therapeutic area


For treatment of neurogenic orthostatic hypotension (NOH) associated with various disorders including Multiple System Atrophy, Familial Amyloid Polyneuropathy, hemodialysis induced hypotension and Parkinson's Disease. Also investigated for use/treatment in neurologic disorders, nephropathy, blood (blood forming organ disorders, unspecified), and dizzy/fainting spells.

Common name


Droxidopa

IUPAC name


(2R,3S)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid

SMILES


N[C@H]([C@@H](O)C1=CC(O)=C(O)C=C1)C(O)=O

INCHI


InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m1/s1

FORMULA


C9H11NO5

Responsive image

Common name


Droxidopa

IUPAC name


(2R,3S)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid

Molecular weight


213.187

clogP


-0.817

clogS


0.662

HBond Acceptor


5

HBond Donor


6

Total Polar
Surface Area


124.01

Number of Rings


1

Rotatable Bond


3

Drug ID Common name Structure CAS SMILE Frequency
FDBF00203 benzene-1,2-diol Responsive image c1cc(c(cc1)O)O 0.0079
1 , 1