
IUPAC name
(2R,3S)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid
SMILES
N[C@H]([C@@H](O)C1=CC(O)=C(O)C=C1)C(O)=O
Compound class
Antiparkinson Agents; Cardiovascular System; Cardiac Therapy; Adrenergic and Dopaminergic Agents; Cardiac Stimulants Excl. Cardiac Glycosides; Beta2 Agonists; Alpha2 Agonists;
Therapeutic area
For treatment of neurogenic orthostatic hypotension (NOH) associated with various disorders including Multiple System Atrophy, Familial Amyloid Polyneuropathy, hemodialysis induced hypotension and Parkinson's Disease. Also investigated for use/treatment in neurologic disorders, nephropathy, blood (blood forming organ disorders, unspecified), and dizzy/fainting spells.
Common name
Droxidopa
IUPAC name
(2R,3S)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid
SMILES
N[C@H]([C@@H](O)C1=CC(O)=C(O)C=C1)C(O)=O
INCHI
InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m1/s1
FORMULA
C9H11NO5

Common name
Droxidopa
IUPAC name
(2R,3S)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid
Molecular weight
213.187
clogP
-0.817
clogS
0.662
HBond Acceptor
5
HBond Donor
6
Total Polar Surface Area
124.01
Number of Rings
1
Rotatable Bond
3
Drug ID | Common name | Structure CAS | SMILE | Frequency |
---|---|---|---|---|
FDBF00203 | benzene-1,2-diol |
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c1cc(c(cc1)O)O | 0.0079 |