IUPAC name
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
SMILES
OC1=C(C=C(Cl)C=C1)C(=O)NC1=C(Cl)C=C(C=C1)[N+]([O-])=O
Compound class
Antinematodal Agents; Anthelmintics; Anticestodal Agents; Antiparasitic Products, Insecticides and Repellents; Phenol Derivatives, Incl. Salicylanilides; Salicylic Acid Derivatives; Anticestodals; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP1A2 Inducers; Cytochrome P-450 CYP2C9 Inducers; Molluscacides;
Therapeutic area
For the treatment of tapeworm and intestinal fluke infections: Taenia saginata (Beef Tapeworm), Taenia solium (Pork Tapeworm), Diphyllobothrium latum (Fish Tapeworm), Fasciolopsis buski (large intestinal fluke). Niclosamide is also used as a molluscicide in the control of schistosomiasis.
Common name
Niclosamide
IUPAC name
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
SMILES
OC1=C(C=C(Cl)C=C1)C(=O)NC1=C(Cl)C=C(C=C1)[N+]([O-])=O
INCHI
InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
FORMULA
C13H8Cl2N2O4
Common name
Niclosamide
IUPAC name
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Molecular weight
327.120
clogP
2.318
clogS
-4.646
HBond Acceptor
4
HBond Donor
2
Total Polar Surface Area
101.14
Number of Rings
2
Rotatable Bond
3
