Responsive image

Common name


Dimetindene

IUPAC name


dimethyl(2-{3-[1-(pyridin-2-yl)ethyl]-1H-inden-2-yl}ethyl)amine

SMILES


CC(C1=C(CCN(C)C)CC2=CC=CC=C12)C1=CC=CC=N1

Compound class


Anti-Allergic Agents; Antipruritics; Histamine H1 Antagonists; Cholinergic Antagonists; Histamine Antagonists; Respiratory System; Dermatologicals; Antipruritics, Incl. Antihistamines, Anesthetics, Etc.; Antihistamines for Topical Use; Antihistamines for Systemic Use; Substituted Alkylamines;

Therapeutic area


Indicated as symptomatic treatment of allergic reactions: urticaria, allergies of the upper respiratory tract such as hey fever and perennial rhinitis, food and drug allergies; pruritus of various origins, except pruritus due to cholestasis; insect bites. Dimethindene is also indicated for pruritus in eruptive skin diseases such as chicken-pox. Dimethindene can also be used as an adjuvant in eczema and other pruriginous dermatoses of allergic origin.

Common name


Dimetindene

IUPAC name


dimethyl(2-{3-[1-(pyridin-2-yl)ethyl]-1H-inden-2-yl}ethyl)amine

SMILES


CC(C1=C(CCN(C)C)CC2=CC=CC=C12)C1=CC=CC=N1

INCHI


InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3

FORMULA


C20H24N2

Responsive image

Common name


Dimetindene

IUPAC name


dimethyl(2-{3-[1-(pyridin-2-yl)ethyl]-1H-inden-2-yl}ethyl)amine

Molecular weight


292.418

clogP


4.614

clogS


-5.480

HBond Acceptor


2

HBond Donor


0

Total Polar
Surface Area


16.13

Number of Rings


3

Rotatable Bond


5

Drug ID Common name Structure CAS SMILE Frequency
FDBF00014 pyridine Responsive image c1cccnc1 0.0333
FDBF00064 N,N-dimethylmethanamine Responsive image N(C)(C)C 0.0371
FDBF00066 N-methylmethanamine Responsive image N(C)C 0.0914
FDBF00289 N,N-dimethylethanamine Responsive image C(C)N(C)C 0.0299
FDBF00585 2-ethylpyridine Responsive image n1c(cccc1)CC 0.0034
FDBF01412 1H-indene Responsive image c1ccc2c(c1)CC=C2 0.0007
7 , 1