IUPAC name
2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide
SMILES
COC1=CC(C(O)CNC(=O)CN)=C(OC)C=C1
Compound class
Vasoconstrictor Agents; Sympathomimetics; Adrenergic alpha-1 Receptor Agonists; Cardiovascular System; Cardiac Therapy; Adrenergic and Dopaminergic Agents; Cardiac Stimulants Excl. Cardiac Glycosides; CYP2D6 Inducers; CYP2D6 Inducers (strong);
Therapeutic area
For the treatment of symptomatic orthostatic hypotension (OH).
Common name
Midodrine
IUPAC name
2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide
SMILES
COC1=CC(C(O)CNC(=O)CN)=C(OC)C=C1
INCHI
InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16)
FORMULA
C12H18N2O4
Common name
Midodrine
IUPAC name
2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide
Molecular weight
254.282
clogP
0.603
clogS
-2.128
HBond Acceptor
4
HBond Donor
4
Total Polar Surface Area
93.81
Number of Rings
1
Rotatable Bond
6
| Drug ID | Common name | Structure CAS | SMILE | Frequency |
|---|---|---|---|---|
| FDBF00003 | formamide |
|
C(=O)N | 0.1240 |
| FDBF00005 | benzene |
|
c1ccccc1 | 0.2824 |
| FDBF00041 | ethanol |
|
CCO | 0.1474 |
| FDBF00308 | 1,4-dimethoxybenzene |
|
c1c(ccc(c1)OC)OC | 0.0014 |
| FDBF00309 | (1R)-1-phenylethanol |
|
CC(O)c1ccccc1 | 0.0034 |
| FDBF00310 | (2-methoxyphenyl)methanol |
|
C(O)c1c(cccc1)OC | 0.0007 |
| FDBF00312 | (1R)-1-(3-methoxyphenyl)ethanol |
|
CC(O)c1cccc(c1)OC | 0.0003 |
| FDBF00314 | (2,5-dimethoxyphenyl)methanol |
|
C(O)c1c(ccc(c1)OC)OC | 0.0007 |
| FDBF00315 | (1R)-1-(2-methoxyphenyl)ethanol |
|
CC(O)c1c(cccc1)OC | 0.0003 |
16 ,
2
