IUPAC name
4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide
SMILES
CC(C)N(CCC(C(N)=O)(C1=CC=CC=C1)C1=NC=CC=C1)C(C)C
Compound class
Anti-Arrhythmia Agents; Voltage-Gated Sodium Channel Blockers; Cardiovascular System; Antiarrhythmics, Class I and Iii; Cardiac Therapy; Antiarrythmics, Class I and Iii; Antiarrhythmics, Class Ia; CYP3A4 Inhibitors;
Therapeutic area
For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias. It is a Class Ia antiarrhythmic drug.
Common name
Disopyramide
IUPAC name
4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide
SMILES
CC(C)N(CCC(C(N)=O)(C1=CC=CC=C1)C1=NC=CC=C1)C(C)C
INCHI
InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25)
FORMULA
C21H29N3O
Common name
Disopyramide
IUPAC name
4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide
Molecular weight
339.474
clogP
3.530
clogS
-4.577
HBond Acceptor
3
HBond Donor
2
Total Polar Surface Area
59.22
Number of Rings
2
Rotatable Bond
8
| Drug ID | Common name | Structure CAS | SMILE | Frequency |
|---|---|---|---|---|
| FDBF00005 | benzene |
|
c1ccccc1 | 0.2824 |
| FDBF00007 | propane |
|
C(C)C | 0.2412 |
| FDBF00193 | propylbenzene |
|
C(c1ccccc1)CC | 0.0186 |
| FDBF00361 | 2-methylpyridine |
|
n1c(cccc1)C | 0.0058 |
| FDBF00590 | (2R)-2-phenylpropanamide |
|
O=C(N)C(c1ccccc1)C | 0.0010 |
| FDBF00592 | 2-propylpyridine |
|
n1c(cccc1)CCC | 0.0017 |
| FDBF00594 | 3-(2-pyridyl)propan-1-amine |
|
NCCCc1ncccc1 | 0.0003 |
| FDBF00596 | (2R)-2-phenyl-2-(2-pyridyl)propanamide |
|
c1(ccccc1)C(C(=O)N)(c2ncccc2)C | 0.0003 |
| FDBF00597 | (2R)-2-phenylbutanamide |
|
c1(ccccc1)C(C(=O)N)CC | 0.0010 |
| FDBF00598 | (2S)-2-(2-pyridyl)butanamide |
|
O=C(N)C(c1ncccc1)CC | 0.0003 |
