Responsive image

Common name


Lidocaine

IUPAC name


2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide

SMILES


CCN(CC)CC(=O)NC1=C(C)C=CC=C1C

Compound class


Anti-Arrhythmia Agents; Voltage-Gated Sodium Channel Blockers; Anesthetics, Local; Anesthetics; Respiratory System; Ophthalmologicals; Sensory Organs; Throat Preparations; Dermatologicals; Nervous System; Cardiovascular System; Antiarrhythmics, Class I and Iii; Cardiac Therapy; Antiarrythmics, Class I and Iii; Antiarrhythmics, Class Ib; Local Anesthetics; Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use; Vasoprotectives; Anesthetics for Topical Use; Antipruritics, Incl. Antihistamines, Anesthetics, Etc.; Amides; Analgesics and Anesthetics; Otologicals; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP1A2 Inducers; Cytochrome P-450 CYP2C8 Inhibitors; Cytochrome P-450 CYP2C9 Inducers; Cytochrome P-450 CYP2C8 Inducers; Cytochrome P-450 CYP2B6 Inducers; Cytochrome P-450 CYP2B6 Inhibitors; CYP2A6 Inhibitors; CYP2A6 Inhibitors (strong); CYP2A6 Inhibitors (moderate); CYP2A6 Inducers; CYP2A6 Inducers (strong); CYP2B6 Inhibitors (strong); CYP2D6 Inducers; CYP2D6 Inducers (strong); CYP3A4 Inhibitors; Combined Inhibitors of CYP3A4 and P-glycoprotein;

Therapeutic area


For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.

Common name


Lidocaine

IUPAC name


2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide

SMILES


CCN(CC)CC(=O)NC1=C(C)C=CC=C1C

INCHI


InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)

FORMULA


C14H22N2O

Responsive image

Common name


Lidocaine

IUPAC name


2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide

Molecular weight


234.337

clogP


2.640

clogS


-4.051

HBond Acceptor


2

HBond Donor


1

Total Polar
Surface Area


32.34

Number of Rings


1

Rotatable Bond


5

Drug ID Common name Structure CAS SMILE Frequency
FDBF00003 formamide Responsive image C(=O)N 0.1240
FDBF00040 ethanamine Responsive image CCN 0.0677
FDBF00068 N-methylethanamine Responsive image N(CC)C 0.0429
FDBF00070 N-ethylethanamine Responsive image N(CC)CC 0.0240
FDBF00294 N-ethyl-N-methyl-ethanamine Responsive image C(C)N(CC)C 0.0134
FDBF00495 N-(2,6-dimethylphenyl)formamide Responsive image O=CNc1c(cccc1C)C 0.0065
FDBF00497 N-(2,6-dimethylphenyl)acetamide Responsive image CC(=O)Nc1c(cccc1C)C 0.0027
FDBF00502 m-xylene Responsive image c1c(cccc1C)C 0.0144
11 , 2