IUPAC name
[2,8-bis(trifluoromethyl)quinolin-4-yl](piperidin-2-yl)methanol
SMILES
OC(C1CCCCN1)C1=CC(=NC2=C1C=CC=C2C(F)(F)F)C(F)(F)F
Compound class
Antimalarials; Antiprotozoal Agents; Antiparasitic Products, Insecticides and Repellents; Methanolquinolines; CYP2D6 Inducers; CYP2D6 Inducers (strong); CYP3A4 Inhibitors; Combined Inhibitors of CYP3A4 and P-glycoprotein;
Therapeutic area
For the treatment of mild to moderate acute malaria caused by Mefloquineuine-susceptible strains of .
Common name
Mefloquine
IUPAC name
[2,8-bis(trifluoromethyl)quinolin-4-yl](piperidin-2-yl)methanol
SMILES
OC(C1CCCCN1)C1=CC(=NC2=C1C=CC=C2C(F)(F)F)C(F)(F)F
INCHI
InChI=1S/C17H16F6N2O/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11/h3-5,8,12,15,24,26H,1-2,6-7H2
FORMULA
C17H16F6N2O
Common name
Mefloquine
IUPAC name
[2,8-bis(trifluoromethyl)quinolin-4-yl](piperidin-2-yl)methanol
Molecular weight
378.312
clogP
4.796
clogS
-5.490
HBond Acceptor
2
HBond Donor
2
Total Polar Surface Area
45.15
Number of Rings
3
Rotatable Bond
4
