IUPAC name
7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
SMILES
CC1NC2=CC(Cl)=C(C=C2C(=O)N1C1=CC=CC=C1C)S(N)(=O)=O
Compound class
Antihypertensive Agents; Diuretics; Sodium Chloride Symporter Inhibitors; Cardiovascular System; Sulfonamides, Plain; Low-Ceiling Diuretics, Excl. Thiazides; Low-Ceiling Diuretics and Potassium-Sparing Agents;
Therapeutic area
For the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class.
Common name
Metolazone
IUPAC name
7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
SMILES
CC1NC2=CC(Cl)=C(C=C2C(=O)N1C1=CC=CC=C1C)S(N)(=O)=O
INCHI
InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)
FORMULA
C16H16ClN3O3S
Common name
Metolazone
IUPAC name
7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
Molecular weight
365.835
clogP
1.407
clogS
-4.510
HBond Acceptor
3
HBond Donor
3
Total Polar Surface Area
92.5
Number of Rings
3
Rotatable Bond
2
