IUPAC name
2,4-dimethyl-8-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-7-one
SMILES
CC1=NC(C)=C2CCC(=O)N(CC3=CC=C(C=C3)C3=CC=CC=C3C3=NNN=N3)C2=N1
Compound class
Cardiovascular System; Angiotensin II Antagonists, Plain; Agents Acting on the Renin-Angiotensin System; CYP3A4 Inhibitors; Angiotensin II Receptor Antagonists;
Therapeutic area
Tasosartan is infrequently in the treatment of hypertension and heart failure.
Common name
Tasosartan
IUPAC name
2,4-dimethyl-8-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-7-one
SMILES
CC1=NC(C)=C2CCC(=O)N(CC3=CC=C(C=C3)C3=CC=CC=C3C3=NNN=N3)C2=N1
INCHI
InChI=1S/C23H21N7O/c1-14-18-11-12-21(31)30(23(18)25-15(2)24-14)13-16-7-9-17(10-8-16)19-5-3-4-6-20(19)22-26-28-29-27-22/h3-10H,11-13H2,1-2H3,(H,26,27,28,29)
FORMULA
C23H21N7O
Common name
Tasosartan
IUPAC name
2,4-dimethyl-8-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-7-one
Molecular weight
411.459
clogP
4.217
clogS
-7.232
HBond Acceptor
6
HBond Donor
1
Total Polar Surface Area
100.55
Number of Rings
5
Rotatable Bond
4
| Drug ID | Common name | Structure CAS | SMILE | Frequency |
|---|---|---|---|---|
| FDBF00005 | benzene |
|
c1ccccc1 | 0.2824 |
| FDBF00023 | toluene |
|
c1(ccccc1)C | 0.1268 |
| FDBF00180 | 5-phenyl-1H-tetrazole |
|
c1c(cccc1)c2[nH]nnn2 | 0.0027 |
| FDBF00188 | tetrazole |
|
[nH]1nnnc1 | 0.0055 |
| FDBF02981 | 2,4,8-trimethyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one |
|
O=C1N(c2nc(nc(c2CC1)C)C)C | 0.0003 |
| FDBF02982 | 2,4-dimethyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one |
|
O=C1Nc2nc(nc(c2CC1)C)C | 0.0003 |
