IUPAC name
1-(2-{[(4-chlorophenyl)methyl]sulfanyl}-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
SMILES
ClC1=CC=C(CSC(CN2C=CN=C2)C2=C(Cl)C=C(Cl)C=C2)C=C1
Compound class
Dermatologicals; Imidazole and Triazole Derivatives; Antifungals for Topical Use; Antifungals for Dermatological Use; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP1A2 Inducers; Cytochrome P-450 CYP2C9 Inducers;
Therapeutic area
Sulconazole solution 1.0% is indicated for the treatment of tinea cruris and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis; and for the treatment of tinea versicolor. Effectiveness has not been proven in tinea pedis (athlete's foot).
Common name
Sulconazole
IUPAC name
1-(2-{[(4-chlorophenyl)methyl]sulfanyl}-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
SMILES
ClC1=CC=C(CSC(CN2C=CN=C2)C2=C(Cl)C=C(Cl)C=C2)C=C1
INCHI
InChI=1S/C18H15Cl3N2S/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2
FORMULA
C18H15Cl3N2S
Common name
Sulconazole
IUPAC name
1-(2-{[(4-chlorophenyl)methyl]sulfanyl}-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
Molecular weight
397.749
clogP
5.801
clogS
-6.671
HBond Acceptor
1
HBond Donor
0
Total Polar Surface Area
43.12
Number of Rings
3
Rotatable Bond
6
| Drug ID | Common name | Structure CAS | SMILE | Frequency |
|---|---|---|---|---|
| FDBF00011 | imidazole |
|
[nH]1ccnc1 | 0.0175 |
| FDBF00016 | chlorobenzene |
|
c1ccc(cc1)Cl | 0.0718 |
| FDBF00052 | methylsulfanylmethane |
|
S(C)C | 0.0072 |
| FDBF00099 | ethanethiol |
|
CCS | 0.0165 |
| FDBF00490 | 1-methylimidazole |
|
n1(ccnc1)C | 0.0058 |
| FDBF00653 | 1-ethylimidazole |
|
C(C)n1ccnc1 | 0.0031 |
| FDBF01459 | 2-imidazol-1-ylethanethiol |
|
C(Cn1ccnc1)S | 0.0007 |
| FDBF02256 | 1-[2-(2,4-dichlorophenyl)ethyl]imidazole |
|
C(Cn1ccnc1)c2c(cc(cc2)Cl)Cl | 0.0021 |
| FDBF03627 | 1-(2-methylsulfanylethyl)imidazole |
|
S(C)CCn1ccnc1 | 0.0003 |
| FDBF03628 | (1R)-1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethanethiol |
|
SC(c1c(cc(cc1)Cl)Cl)Cn2ccnc2 | 0.0003 |
