Responsive image

IUPAC name


{[(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl]methoxy}phosphonic acid

SMILES


CN1N=NC(=N1)C1=CC=C(C=N1)C1=CC=C(C=C1F)N1C[C@H](COP(O)(O)=O)OC1=O

Compound class


Anti-Bacterial Agents; Antibacterials for Systemic Use; Antiinfectives for Systemic Use;

Therapeutic area


Tedizolid Phosphate is an oxazolidinone antibacterial drug indicated in adults for the treatment of acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible isolates of the following Gram-positive microorganisms: Staphylococcus aureus (including methicillin-resistant [MRSA] and methicillin-susceptible [MSSA] isolates), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus anginosus Group (including Streptococcus anginosus, Streptococcus intermedius, and Streptococcus constellatus), and Enterococcus faecalis.

Common name


Tedizolid Phosphate

IUPAC name


{[(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl]methoxy}phosphonic acid

SMILES


CN1N=NC(=N1)C1=CC=C(C=N1)C1=CC=C(C=C1F)N1C[C@H](COP(O)(O)=O)OC1=O

INCHI


InChI=1S/C17H16FN6O6P/c1-23-21-16(20-22-23)15-5-2-10(7-19-15)13-4-3-11(6-14(13)18)24-8-12(30-17(24)25)9-29-31(26,27)28/h2-7,12H,8-9H2,1H3,(H2,26,27,28)/t12-/m1/s1

FORMULA


C17H16FN6O6P

Responsive image

Common name


Tedizolid Phosphate

IUPAC name


{[(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl]methoxy}phosphonic acid

Molecular weight


450.318

clogP


-0.134

clogS


-2.539

HBond Acceptor


10

HBond Donor


2

Total Polar
Surface Area


152.79

Number of Rings


4

Rotatable Bond


6

Drug ID Common name Structure CAS SMILE Frequency
FDBF00014 pyridine Responsive image c1cccnc1 0.0333
FDBF00378 fluorobenzene Responsive image Fc1ccccc1 0.0237
FDBF00707 oxazolidin-2-one Responsive image O1CCNC1=O 0.0024
FDBF01339 3-(3-fluorophenyl)oxazolidin-2-one Responsive image O1CCN(C1=O)c2cccc(c2)F 0.0007
FDBF01341 (5S)-5-methyloxazolidin-2-one Responsive image CC1OC(=O)NC1 0.0014
FDBF01342 (5S)-3-(3-fluorophenyl)-5-methyl-oxazolidin-2-one Responsive image CC1OC(=O)N(C1)c2cccc(c2)F 0.0007
FDBF04010 3-[3-fluoro-4-(3-pyridyl)phenyl]oxazolidin-2-one Responsive image Fc1cc(ccc1c2cnccc2)N3CCOC3=O 0.0003
FDBF04011 (5S)-3-[3-fluoro-4-(3-pyridyl)phenyl]-5-methyl-oxazolidin-2-one Responsive image Fc1cc(ccc1c2cnccc2)N3CC(OC3=O)C 0.0003
FDBF04012 2-methyltetrazole Responsive image n1n(nnc1)C 0.0010
9 , 1