Responsive image

Common name


Azithromycin

IUPAC name


(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-2-ethyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one

SMILES


CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O

Compound class


Anti-Bacterial Agents; Macrolides; Antibiotics; Ophthalmologicals; Sensory Organs; Antibacterials for Systemic Use; Antiinfectives for Systemic Use; Antiinfectives; Macrolides, Lincosamides and Streptogramins; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP1A2 Inducers; CYP2A6 Inhibitors; CYP2A6 Inhibitors (strong); CYP2A6 Inhibitors (moderate); CYP2A6 Inducers; CYP2A6 Inducers (strong); CYP3A4 Inhibitors; Combined Inhibitors of CYP3A4 and P-glycoprotein;

Therapeutic area


For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions: .

Common name


Azithromycin

IUPAC name


(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-2-ethyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one

SMILES


CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O

INCHI


InChI=1S/C38H72N2O12/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28/h20-33,35,41-43,45-46H,15-19H2,1-14H3/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1

FORMULA


C38H72N2O12

Responsive image

Common name


Azithromycin

IUPAC name


(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-2-ethyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one

Molecular weight


748.984

clogP


0.237

clogS


-2.223

HBond Acceptor


14

HBond Donor


5

Total Polar
Surface Area


180.08

Number of Rings


3

Rotatable Bond


7

Drug ID Common name Structure CAS SMILE Frequency
FDBF00066 N-methylmethanamine Responsive image N(C)C 0.0914
FDBF00274 (2R,4S,5S,6R)-4,6-dimethyltetrahydropyran-2,5-diol Responsive image OC1OC(C(C(C1)C)O)C 0.0014
FDBF00275 (2R,3R,4R)-4-methoxy-2,4-dimethyl-tetrahydropyran-3-ol Responsive image O(C)C1(CCOC(C1O)C)C 0.0014
FDBF00278 (2R,3S,4S)-2,4-dimethyltetrahydropyran-3-ol Responsive image O1CCC(C(C1C)O)C 0.0014
FDBF00299 (2S,3R,6S)-6-methyltetrahydropyran-2,3-diol Responsive image C1(C(OC(CC1)C)O)O 0.0007
FDBF00300 (3R,4S,6S)-4-(dimethylamino)-6-methyl-tetrahydropyran-3-ol Responsive image C1(COC(CC1N(C)C)C)O 0.0007
FDBF00301 (3R,6S)-6-methyltetrahydropyran-3-ol Responsive image C1(COC(CC1)C)O 0.0007
7 , 1